发明申请
- 专利标题: TEMPLATE-FIXED PEPTIDOMIMETICS
- 专利标题(中): 模板固定蛋白质
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申请号: US12528926申请日: 2007-02-28
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公开(公告)号: US20100048463A1公开(公告)日: 2010-02-25
- 发明人: Daniel Obrecht , Frank Gombert , Steven J. Demarco , Christian Ludin , Jan Wim Vrijbloed , Kerstin Moehle , John-Anthony Robinson , Reshmi Mukherjee , Heiko Henze , Barbara Romagnoli
- 申请人: Daniel Obrecht , Frank Gombert , Steven J. Demarco , Christian Ludin , Jan Wim Vrijbloed , Kerstin Moehle , John-Anthony Robinson , Reshmi Mukherjee , Heiko Henze , Barbara Romagnoli
- 申请人地址: CH Allschwil CH Zuerich
- 专利权人: POLYPHOR Ltd.,Universitaet Zuerich
- 当前专利权人: POLYPHOR Ltd.,Universitaet Zuerich
- 当前专利权人地址: CH Allschwil CH Zuerich
- 国际申请: PCT/CH07/00101 WO 20070228
- 主分类号: C07K7/56
- IPC分类号: C07K7/56 ; A61K38/12 ; A61P31/12 ; A61P31/18
摘要:
The template-fixed B-hairpin peptidomimetics Cyclo(-Tyr-His-X-Cys-Ser-Ala-DPro-Dab-Arg-Tyr-Cys-Tyr-Gln-Lys-DPro-Pro), disulfide bond between Cys4 and Gys11, and pharmaceutically acceptable salts thereof, with X being Ala or Tyr, have CXCR4 antagonizing properties and can be used for preventing HIV infections in healthy individuals or for slowing and halting viral progression in infected patients; or where Cancer is mediated or resulting from CXCR4 receptor activity; or where immunological diseases are mediated or resulting from CXCR4 receptor activity; or for treating immuno suppression; or, in particular, for stem cell mobilisation of peripheral blood stem cells and/or mesenchymal stem cell (MSC) and/or other stem cells which retention depend on the CXCR4-receptor. These β-hairpin peptidomimetics can be manufactured by a process which is based on a mixed solid- and Solution phase synthetic strategy, using methods which are well known to those adequately skilled in peptide chemistry.
公开/授权文献
- US08399611B2 Template-fixed peptidomimetics 公开/授权日:2013-03-19