发明申请
US20100048479A1 ADRENAL GRK2 ACTIVITY AS A THERAPEUTIC TARGET FOR HEART FAILURE
审中-公开
ADRENAL GRK2活动作为心脏失效的治疗目标
- 专利标题： ADRENAL GRK2 ACTIVITY AS A THERAPEUTIC TARGET FOR HEART FAILURE
- 专利标题（中）： ADRENAL GRK2活动作为心脏失效的治疗目标
-
申请号： US12513713申请日： 2007-11-09
-
公开(公告)号： US20100048479A1公开(公告)日： 2010-02-25
- 发明人: Anastasios Lymperopoulos , Walter J. Koch
- 申请人： Anastasios Lymperopoulos , Walter J. Koch
- 申请人地址： US PA Philadelphia
- 专利权人： THOMAS JEFFERSON UNIVERSITY
- 当前专利权人： THOMAS JEFFERSON UNIVERSITY
- 当前专利权人地址： US PA Philadelphia
- 国际申请： PCT/US2007/023628 WO 20071109
- 主分类号： A61K38/16
- IPC分类号： A61K38/16 ; A61K31/711 ; A61K31/7105 ; A61P9/10
摘要：
The present invention relates to compositions and methods for the treatment of failing hearts. More specifically, the present invention provides for the inhibition of G-protein coupled receptor kinase 2 activity in the adrenal gland, which, for example, decreases catecholamine secretion and the sympathetic burden of the failing heart, thereby improving the cardiac adrenergic/inotropic reserve and overall contractile function.