发明申请
- 专利标题： COMPOUNDS AND COMPOSITIONS AS PROTEIN KINASE INHBITORS
- 专利标题（中）： 作为蛋白激酶抑制剂的化合物和组合物
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申请号： US12299687申请日： 2007-05-11
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公开(公告)号： US20100048552A1公开(公告)日： 2010-02-25
- 发明人: Pingda Ren , Baogen Wu , Guobao Zhang , Yongping Xie , Barun Okram , Victor Nikulin , Xia Wang , Ha-Soon Choi
- 申请人： Pingda Ren , Baogen Wu , Guobao Zhang , Yongping Xie , Barun Okram , Victor Nikulin , Xia Wang , Ha-Soon Choi
- 申请人地址： BM Hamilton
- 专利权人： IRM LLC
- 当前专利权人： IRM LLC
- 当前专利权人地址： BM Hamilton
- 国际申请： PCT/US2007/068819 WO 20070511
- 主分类号： A61K31/4375
- IPC分类号： A61K31/4375 ; C07D471/14 ; A61K31/5377 ; A61P43/00
摘要：
The invention provides a novel class of compounds, pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with abnormal or deregulated kinase activity, particularly diseases or disorders that involve abnormal activation of the Abl, Bcr-Abl, Bcr-Abl(T315I), ALK, BLK, BMX, BRK, C-kit, c-RAF, CSK, c-SRC, EGFR, Fes, FGFR3, Flt3, Fms, Fyn, IGF-1R, IR, JAK(2), JAK(3), KDR, Lck, NLK, p70S6K, PDGFRα, Ros, SAPK2α, SGK, SIK, Syk, Tie2 and TrkB kinases.
公开/授权文献
- US07846923B2 Compounds and compositions as protein kinase inhbitors 公开/授权日：2010-12-07
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