Example methods and apparatus to perform pressure testing of geological formations are disclosed. A disclosed example method comprises positioning a testing tool in a wellbore formed in the geological formation, sealing a sample interval around the testing tool, sealing a first guard interval around the testing tool and adjacent to the sample interval, reducing a first pressure in the sample interval, reducing a second pressure in the first guard interval, maintaining a volume of a first chamber fluidly coupled to the sample interval during a time interval, and measuring a plurality of pressure data for a fluid captured in the first chamber during the time interval.