发明申请
US20100055128A1 METHOD FOR THE PURIFICATION OF ALPHAVIRUS REPLICON PARTICLES
审中-公开
ALPHAVIRUS REPLICON颗粒的纯化方法
- 专利标题： METHOD FOR THE PURIFICATION OF ALPHAVIRUS REPLICON PARTICLES
- 专利标题（中）： ALPHAVIRUS REPLICON颗粒的纯化方法
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申请号： US12212978申请日： 2008-09-18
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公开(公告)号： US20100055128A1公开(公告)日： 2010-03-04
- 发明人: John M. Polo , Catherine Greer , Maria Calderon-Cacia , Daniel De La Vega, JR. , Thomas W. Dubensky, JR.
- 申请人： John M. Polo , Catherine Greer , Maria Calderon-Cacia , Daniel De La Vega, JR. , Thomas W. Dubensky, JR.
- 申请人地址： US CA Emeryville
- 专利权人： Novartis Vaccines and Diagnostics Inc
- 当前专利权人： Novartis Vaccines and Diagnostics Inc
- 当前专利权人地址： US CA Emeryville
- 主分类号： A61K39/12
- IPC分类号： A61K39/12 ; C12N7/02
摘要：
Methods of production and purification for viruses and virus-derived vectors, including those related to alphaviruses, are disclosed. in one aspect, methods of purification that subject alphavirus replicon particle preparations to one or more steps of chromatographic purification, such as using an ion exchange resin, are provided. Also disclosed are methods of characterizing alphavirus replicon particles and utilizing these materials for vaccines and gene-based therapeutics.
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