发明申请
- 专利标题： Tubulin Mutation Diagnostic
- 专利标题（中）： 微管蛋白突变诊断
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申请号： US12610400申请日： 2009-11-02
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公开(公告)号： US20100055709A1公开(公告)日： 2010-03-04
- 发明人: Kenneth Wayne Culver , Markus Wartmann , Stan Lilleberg , Jian Zhu
- 申请人： Kenneth Wayne Culver , Markus Wartmann , Stan Lilleberg , Jian Zhu
- 优先权： GB0425038.7 20041112
- 主分类号： C12Q1/68
- IPC分类号： C12Q1/68 ; C07H21/04 ; C07K14/435 ; C12Q1/02
摘要：
The present invention relates to methods for determining the potential of a subject to respond to a particular therapeutic agent, by determining the presence of one or more nucleotide or amino acid variants in the β-tubulin gene or protein. Also provided are methods for treating subjects whose potential to respond to a therapeutic agent has been evaluated. For use in the methods of the invention, there are provided variants of the β-tubulin gene. variants of the β-tubulin protein, nucleic acid molecules and agents which bind to the variant β-tubulin nucleic acid molecules and variant β-tubulin protein, respectively, and kits comprising the same.
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