- 专利标题： GLUCOKINASE ACTIVATORS
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申请号： US12092233申请日： 2006-10-24
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公开(公告)号： US20100056530A1公开(公告)日： 2010-03-04
- 发明人: Thomas D. Aicher , Wai-man Lee , Ronald Jay Hinklin , Mark Joseph Chicarelli , Steven Armen Boyd , Kevin Ronald Condroski
- 申请人： Thomas D. Aicher , Wai-man Lee , Ronald Jay Hinklin , Mark Joseph Chicarelli , Steven Armen Boyd , Kevin Ronald Condroski
- 申请人地址： US CO Boulder
- 专利权人： ARRAY BIOPHARMA INC.
- 当前专利权人： ARRAY BIOPHARMA INC.
- 当前专利权人地址： US CO Boulder
- 国际申请： PCT/US06/41251 WO 20061024
- 主分类号： A61K31/498
- IPC分类号： A61K31/498 ; C07D417/12 ; C07D401/14 ; C07D241/36 ; A61K31/4439 ; A61K31/444 ; A61P3/10
摘要：
Provided are compounds of Formula I wherein R1, R2, Y, Z and G are as defined herein, that are useful in the treatment and/or prevention of diseases mediated by deficient levels of glucokinase activity, such as diabetes mellitus. Also provided are methods of treating or preventing diseases and disorders characterized by underactivity of glucokinase or which can be treated by activating glucokinase.
公开/授权文献
- US08933077B2 Glucokinase activators 公开/授权日：2015-01-13