发明申请
US20100056790A1 FLUORO-CONTAINING DERIVATIVES OF HYDROGENATED PYRIDO[4,3-B]INDOLES WITH NEUROPROTECTIVE AND COGNITION ENHANCING PROPERTIES, PROCESS FOR PREPARING, AND USE
有权
具有神经保护和加强增强性能的氢化吡咯并[4,3-B]吲哚的含氟衍生物,制备和使用方法
- 专利标题: FLUORO-CONTAINING DERIVATIVES OF HYDROGENATED PYRIDO[4,3-B]INDOLES WITH NEUROPROTECTIVE AND COGNITION ENHANCING PROPERTIES, PROCESS FOR PREPARING, AND USE
- 专利标题(中): 具有神经保护和加强增强性能的氢化吡咯并[4,3-B]吲哚的含氟衍生物,制备和使用方法
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申请号: US12621464申请日: 2009-11-18
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公开(公告)号: US20100056790A1公开(公告)日: 2010-03-04
- 发明人: Alexey Aksinenko , Sergey Bachurin , Sergey Sablin , Bogdan Beznosko , Nadezhda Beznosko , Vladimir Sokolov
- 申请人: Alexey Aksinenko , Sergey Bachurin , Sergey Sablin , Bogdan Beznosko , Nadezhda Beznosko , Vladimir Sokolov
- 申请人地址: US CA San Francisco
- 专利权人: D2E, LLC
- 当前专利权人: D2E, LLC
- 当前专利权人地址: US CA San Francisco
- 主分类号: C07D471/02
- IPC分类号: C07D471/02
摘要:
Some exemplary embodiments comprise fluoro-containing derivatives of pyrido[4,3-b]indoles (and exemplary methods of making the same) that may be administered to a mammal (including a human) in an effective amount for potential use in the treatment or prophylaxis of neurological disorders including AD, mild cognitive impairment, senile and vascular dementia, HD, ALS, Parkinson's disease, AIDS-related dementia, ischaemic cerebral pathologies, neuropathic pain, ADHD (attention deficit disorder/hyperactivity syndrome), eating disorders such as anorexia and bulimia, panic attacks, withdrawal from drug abuse such as cocaine, ethanol, nicotine and benzodiazepines, schizophrenia (in particular the cognitive deficit of schizophrenia), stroke and also disorders associated with spinal trauma and/or head injury. These derivatives may also be useful for the treatment of borderline personality disorder, obesity, and for use as geroprotectors. The compounds may also be used as “pharmacological tools” for an investigation of the mechanism of protection against neurodegeneration disorders in vivo or in vitro.