A system and method in a virtual universe system for triggering scans of virtual items and inventories of virtual items and for scanning the virtual items and inventories wherein the scans may be triggered by an avatar moving or teleporting from one region to another, or by an avatar picking up, dropping off, or accepting or purchasing an item. The degree of scanning may depend upon factors such as location where these scan triggers occur. The signature of the item may be identified by the scan process. The item signature may be compared against signatures of known malicious items stored in an inventory item signatures database and a summary of the signature comparison may be sent to a resident and stored in the resident's inventory.