Invention Application
- Patent Title: RAF INHIBITOR COMPOUNDS AND METHODS OF USE THEREOF
- Patent Title (中): RAF抑制剂化合物及其使用方法
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Application No.: US12438967Application Date: 2007-08-31
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Publication No.: US20100063066A1Publication Date: 2010-03-11
- Inventor: Alexandre J. Buckmelter , Joseph P. Lyssikatos , Greg Miknia , Li Ren , Steven Mark Wenglowsky , Bryson Rast
- Applicant: Alexandre J. Buckmelter , Joseph P. Lyssikatos , Greg Miknia , Li Ren , Steven Mark Wenglowsky , Bryson Rast
- Applicant Address: US CO Boulder
- Assignee: Array Biopharma, Inc.
- Current Assignee: Array Biopharma, Inc.
- Current Assignee Address: US CO Boulder
- Priority: USPCT/US2006/033976 20060831
- International Application: PCT/US07/77411 WO 20070831
- Main IPC: A61K31/497
- IPC: A61K31/497 ; C07D401/14 ; C07D471/04 ; A61K31/4439 ; A61P35/00

Abstract:
Compounds of Formulas (I), (IIA) and (IIIA) are useful for inhibiting Raf kinase and for treating disorders mediated thereby. Methods of using compounds of Formulas (I), (IIA) and (IIIA) and stereoisomers and pharmaceutically acceptable salts thereof, for in vitro, in situ, and in vivo diagnosis, prevention or treatment of such disorders in mammalian cells, or associated pathological conditions are disclosed.
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