Invention Application
- Patent Title: LXR and FXR Modulators
- Patent Title (中): LXR和FXR调制器
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Application No.: US12517800Application Date: 2007-12-07
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Publication No.: US20100069367A1Publication Date: 2010-03-18
- Inventor: Brant Clayton Boren , Brett B. Busch , Xiao-Hui Gu , Vasu Jammalamadaka , Shao Po Lu , Richard Martin , Raju Mohan , Edwin Schweiger , William C. Stevens , Tie-Lin Wang , Yinong Xie , Wei Xu
- Applicant: Brant Clayton Boren , Brett B. Busch , Xiao-Hui Gu , Vasu Jammalamadaka , Shao Po Lu , Richard Martin , Raju Mohan , Edwin Schweiger , William C. Stevens , Tie-Lin Wang , Yinong Xie , Wei Xu
- Applicant Address: US CA South San Francisco
- Assignee: EXELIXIS, INC.
- Current Assignee: EXELIXIS, INC.
- Current Assignee Address: US CA South San Francisco
- International Application: PCT/US2007/086787 WO 20071207
- Main IPC: A61K31/551
- IPC: A61K31/551 ; C07D231/12 ; A61K31/415 ; C07D233/54 ; A61K31/4164 ; C07D215/38 ; A61K31/47 ; C07D413/02 ; A61K31/421 ; C07D277/08 ; A61K31/426 ; C07D271/06 ; A61K31/4245 ; C07D403/02 ; A61K31/505 ; C07D401/02 ; A61K31/4439 ; A61K31/5377 ; C07D401/14 ; A61K31/496 ; C07D243/08 ; A61P9/00 ; A61P25/00 ; A61P35/00 ; A61P29/00 ; A61P3/00 ; A61P37/00

Abstract:
Compounds of the invention are disclosed, such as compounds of formulae LX-LXIV, and pharmaceutically acceptable salts, isomers, or prodrugs thereof, which are useful as modulators of the activity of liver X receptors (LXR) and Farnesoid X receptors (FXR), where R00, R200, R400, R500, J11, J21, G1, G21, and Q are defined herein. Pharmaceutical compositions containing the compounds and methods of using the compounds are also disclosed.
Public/Granted literature
- US07998995B2 LXR and FXR modulators Public/Granted day:2011-08-16
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