发明申请
- 专利标题: N-HYDROXYACRYLAMIDE COMPOUNDS
- 专利标题(中): N-羟基丙烯酰胺化合物
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申请号: US12517290申请日: 2007-12-14
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公开(公告)号: US20100069388A1公开(公告)日: 2010-03-18
- 发明人: Yoshikazu Inoue , Yoshiteru Eikyu , Fumiyuki Shirai
- 申请人: Yoshikazu Inoue , Yoshiteru Eikyu , Fumiyuki Shirai
- 申请人地址: JP TOKYO
- 专利权人: ASTELLAS PHARMA INC.
- 当前专利权人: ASTELLAS PHARMA INC.
- 当前专利权人地址: JP TOKYO
- 国际申请: PCT/JP2007/074605 WO 20071214
- 主分类号: A61K31/5377
- IPC分类号: A61K31/5377 ; C07D211/72 ; C07D241/02 ; C07D413/12 ; A61K31/44 ; A61K31/4965 ; A61P3/10
摘要:
A compound having the following formula (I): wherein —R1 is hydrogen, optionally substituted lower alkyl, cyclo(lower)alkyl, cyclo(higher)alkyl, optionally substituted aryl, optionally substituted heterocyclyl, or aryl-fused cyclo(lower)alkyl, R2 is hydrogen or halogen, Z is CH or N, X is formula (II) R3 is lower alkyl which may be substituted with —OH or optionally substituted aryl, or lower alkanoyl, R4 is hydrogen or lower alkyl, Y is optionally substituted lower alkylene, or a salt thereof. The compound is useful as a histone deacetylase inhibitor.