发明申请
- 专利标题: Process for preparing difluoromethylpyrazolyl carboxylates
- 专利标题(中): 制备二氟甲基吡唑羧酸酯的方法
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申请号: US12513003申请日: 2007-11-02
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公开(公告)号: US20100069646A1公开(公告)日: 2010-03-18
- 发明人: Martin Sukopp , Michael Rack , Sebastian Peer Smidt , Sandra Löhr , Michael Keil , Jochen Dietz , Joachim Rheinheimer , Thomas Grote , Thomas Zierke , Jan Klaas Lohmann
- 申请人: Martin Sukopp , Michael Rack , Sebastian Peer Smidt , Sandra Löhr , Michael Keil , Jochen Dietz , Joachim Rheinheimer , Thomas Grote , Thomas Zierke , Jan Klaas Lohmann
- 申请人地址: DE Ludwigshafen
- 专利权人: BASF SE
- 当前专利权人: BASF SE
- 当前专利权人地址: DE Ludwigshafen
- 优先权: EP06123461.3 20061103
- 国际申请: PCT/EP07/61833 WO 20071102
- 主分类号: C07D231/10
- IPC分类号: C07D231/10 ; C07F7/08
摘要:
The present invention relates to a process for preparing difluoromethyl-substituted pyrazol-4-ylcarboxylates of the formula I in which R1 is C1-C8-alkyl, C3-C8-cycloalkyl, C1-C4-alkoxy-C1-C4-alkyl, etc.; and R2 is hydrogen, C1-C4-alkyl, benzyl or phenyl, wherein a) a compound of the general formula II in which X is fluorine, chlorine or bromine, R1 has one of the meanings given above and R4 is C1-C8-alkyl, C3-C8-cycloalkyl, C2-C8-alkenyl, benzyl or phenyl, is reacted with a silane compound of the general formula R3nSiCl(4-n) in which n is 1, 2 or 3 and the substituents R3 are independently of one another selected from the group consisting of C1-C8-alkyl and phenyl and with a metal selected from the metals of groups 1, 2, 3, 4 and 12 of the Periodic Table of the Elements having a redox potential of less than −0.7 V, based on a normal hydrogen electrode (at 25° C. and 101.325 kPa); and b) the reaction mixture from step a) is reacted with a compound of the general formula III R2HN—NH2 (III) in which R2 has one of the meanings given above.
公开/授权文献
- US08115012B2 Process for preparing difluoromethylpyrazolyl carboxylates 公开/授权日:2012-02-14
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