发明申请
US20100075954A1 SUBSTITUTED IMIDAZO[1,5-A][1,2,4]TRIAZOLO[1,5-D][1,4]BENZODIAZEPINE DERIVATIVES
失效
取代的咪唑并[1,5-A] [1,2,4]三唑并[1,5-D] [1,4]苯并恶嗪衍生物
![SUBSTITUTED IMIDAZO[1,5-A][1,2,4]TRIAZOLO[1,5-D][1,4]BENZODIAZEPINE DERIVATIVES](/docs/US/2010-03-25/US20100075954A1/abs.jpg.600x600.jpg)
- 专利标题： SUBSTITUTED IMIDAZO[1,5-A][1,2,4]TRIAZOLO[1,5-D][1,4]BENZODIAZEPINE DERIVATIVES
- 专利标题（中）： 取代的咪唑并[1,5-A] [1,2,4]三唑并[1,5-D] [1,4]苯并恶嗪衍生物
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申请号： US12618802申请日： 2009-11-16
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公开(公告)号： US20100075954A1公开(公告)日： 2010-03-25
- 发明人: Henner Knust , Heinz Stadler , Andrew William Thomas
- 申请人： Henner Knust , Heinz Stadler , Andrew William Thomas
- 优先权： EP04105000.6 20041012
- 主分类号： A61K31/551
- IPC分类号： A61K31/551 ; C07D243/10 ; A61P25/28
![SUBSTITUTED IMIDAZO[1,5-A][1,2,4]TRIAZOLO[1,5-D][1,4]BENZODIAZEPINE DERIVATIVES](/abs-image/US/2010/03/25/US20100075954A1/abs.jpg.150x150.jpg)
摘要：
The present invention is concerned with a method of treating Alzheimer's disease by administering a therapeutically effective amount of a substituted imidazo[1,5-a][1,2,4]triazolo[1,5-d][1,4]benzodiazepine of formula I wherein R1, R2, and R3 are as defined herein, and their pharmaceutically acceptable acid addition salts. The invention also provides novel compounds of formula I-A and pharmaceutical compositions containing them.