In a medicine packaging machine including a medicine accommodating mechanism for accommodating plural medicines, a chute for guiding medicines arbitrarily taken out from the medicine accommodating mechanism to a medicine packaging sheet, and a medicine packaging mechanism having a heater for thermally welding the medicine packaging sheet, the heater is provided with an incision tooth for forming an incision at an edge portion of the medicine packaging sheet at the same time when the medicine packaging sheet filled with the medicines. Furthermore, a cutting mechanism for cutting at a predetermined position a separate package bag formed by thermally welding the medicine packaging sheet is provided.