In an optical transmission system, a controller acquires a noise light loss value, which indicates a loss that noise light output from an upstream-side optical amplifier undergoes during propagation to a downstream-side optical amplifier through an optical loss medium, and a signal beam loss value, which indicates a loss that a signal beam output from the upstream-side optical amplifier undergoes during propagation to the downstream-side optical amplifier through the optical loss medium, obtains, as a loss difference, a difference between the noise light loss value and the signal beam loss value and, when setting up the downstream-side optical amplifier, determines the gain of the downstream-side optical amplifier by compensating the loss difference.