Call stack protection, including executing at least one application program on the one or more computer processors, including initializing threads of execution, each thread having a call stack, each call stack characterized by a separate guard area defining a maximum extent of the call stack, dispatching one of the threads of the process, including loading a guard area specification for the dispatched thread's call stack guard area from thread context storage into address comparison registers of a processor; determining by use of address comparison logic in dependence upon a guard area specification for the dispatched thread whether each access of memory by the dispatched thread is a precluded access of memory in the dispatched thread's call stack's guard area; and effecting by the address comparison logic an address comparison interrupt for each access of memory that is a precluded access of memory in the dispatched thread's guard area.