发明申请
- 专利标题： COMPOSITIONS AND METHODS FOR TREATMENT OF EYE DISORDERS
- 专利标题（中）： 用于治疗眼病的组合物和方法
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申请号： US12508311申请日： 2009-07-23
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公开(公告)号： US20100092541A1公开(公告)日： 2010-04-15
- 发明人: John Burnier , Thomas Gadek , Min Zhong
- 申请人： John Burnier , Thomas Gadek , Min Zhong
- 主分类号： A61K9/00
- IPC分类号： A61K9/00 ; C07D405/06 ; A61K31/4725 ; A61K9/127 ; A61K9/12
摘要：
The present invention provides compounds and methods for the treatment of LFA-1 mediated diseases. In particular, LFA-1 antagonists are described herein and these antagonists are used in the treatment of LFA-1 mediated diseases. One aspect of the invention provides for diagnosis of an LFA-1 mediated disease and administration of a LFA-1 antagonist, after the patient is diagnosed with a LFA-1 mediated disease. In some embodiments, the LFA-1 mediated diseases treated are dry eye disorders. Also provided herein are methods for identifying compounds which are LFA-1 antagonists.
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