发明申请
- 专利标题： PRODUCTION OF SECRETED PROTEINS BY FILAMENTOUS FUNGI
- 专利标题（中）： 通过真菌生产分泌蛋白
-
申请号： US12444760申请日： 2007-10-31
-
公开(公告)号： US20100093030A1公开(公告)日： 2010-04-15
- 发明人: Cornelis Maria Jacobus Sagt , Cornelis Theodorus Verrips , Walraven Henry Muller , Noël Nicolaas Maria Elisabeth Van Peij
- 申请人： Cornelis Maria Jacobus Sagt , Cornelis Theodorus Verrips , Walraven Henry Muller , Noël Nicolaas Maria Elisabeth Van Peij
- 优先权： EP06123392.0 20061102
- 国际申请： PCT/EP2007/061765 WO 20071031
- 主分类号： C12N15/80
- IPC分类号： C12N15/80 ; C07H21/04 ; C07K14/37 ; C12N1/15 ; C12P21/00
摘要：
The present invention relates to a method to improve the secretion of a protein of interest by a filamentous fungal cell comprising inducing a phenotype in the cell selected from the group consisting of a lowered ERAD, an elevated UPR that does not induce an elevated ERAD, wherein ERAD preferably is lowered. The invention further relates to the filamentous fungal cell comprising the phenotype described above. The invention also relates to polynucleotides and polypeptides whose expression can be modulated in the filamentous fungal cell to obtain the above-described phenotype.
公开/授权文献
- US08389269B2 Production of secreted proteins by filamentous fungi 公开/授权日：2013-03-05
信息查询
IPC分类:
