发明申请
US20100093611A1 COMPOUNDS AND METHODS FOR TREATING OR PREVENTING AUTOIMMUNE DISEASES
审中-公开
用于治疗或预防自身免疫性疾病的化合物和方法
- 专利标题： COMPOUNDS AND METHODS FOR TREATING OR PREVENTING AUTOIMMUNE DISEASES
- 专利标题（中）： 用于治疗或预防自身免疫性疾病的化合物和方法
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申请号： US12451539申请日： 2008-05-16
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公开(公告)号： US20100093611A1公开(公告)日： 2010-04-15
- 发明人: Stephen K. Horrigan , Qin Zong , Daniel Soppet , Juana Castaneda , Bo Chen , Ricardo Cibotti , Laurent P. Audoly , Anthony Coyle , Peter Kiener
- 申请人： Stephen K. Horrigan , Qin Zong , Daniel Soppet , Juana Castaneda , Bo Chen , Ricardo Cibotti , Laurent P. Audoly , Anthony Coyle , Peter Kiener
- 国际申请： PCT/US2008/006345 WO 20080516
- 主分类号： A61K38/12
- IPC分类号： A61K38/12 ; A61K31/435 ; A61K31/515 ; A61K31/551 ; A61P37/06
摘要：
Methods of treating, ameliorating, preventing, or reducing the risk of developing an auto-immune disease and/or an inflammatory condition, such as systemic lupus erythematosus, in a patient, such as a human being, using a therapeutically effective amount of an agent(s) that inhibits the activity of one or more of histone deacetylase (HDAC), IKB kinase (IKK-2), nuclear factor kB (NF-kB), ubiquitin/proteasome and Janus kinase (JAK) are disclosed. Compounds useful in such methods are also presented.
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