发明申请
- 专利标题: NOVEL FUSED AMINODIHYDROTHIAZINE DERIVATIVE
- 专利标题(中): 新型融合氨基吡啶衍生物
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申请号: US12568151申请日: 2009-09-28
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公开(公告)号: US20100093999A1公开(公告)日: 2010-04-15
- 发明人: Takafumi Motoki , Kunitoshi Takeda , Yoichi Kita , Mamoru Takaishi , Yuichi Suzuki , Tasuku Ishida
- 申请人: Takafumi Motoki , Kunitoshi Takeda , Yoichi Kita , Mamoru Takaishi , Yuichi Suzuki , Tasuku Ishida
- 申请人地址: JP Tokyo
- 专利权人: EISAI R&D MANAGEMENT CO., LTD.
- 当前专利权人: EISAI R&D MANAGEMENT CO., LTD.
- 当前专利权人地址: JP Tokyo
- 优先权: JP2008-252062 20080930; JP2009-100457 20090417; JP2009-168490 20090717
- 主分类号: C07D498/04
- IPC分类号: C07D498/04
摘要:
A compound represented by the general formula: wherein Ring A is a C6-14 aryl group or the like, L is —NRLCO— or the like (wherein RL is a hydrogen atom or the like), Ring B is a C6-14 aryl group or the like, X is a C1-3 alkylene group or the like, Y is a C1-3 alkylene group or the like, Z is an oxygen atom or the like, R1 and R2 are each independently a hydrogen atom or the like, and R3, R4, R5 and R6 are independently a hydrogen atom, a halogen atom or the like, or a pharmaceutically acceptable salt thereof, or a solvate thereof, has an Aβ production inhibitory effect or a BACE1 inhibitory effect and is useful as a therapeutic agent for a neurodegenerative disease caused by Aβ and typified by Alzheimer-type dementia.
公开/授权文献
- US08198269B2 Fused aminodihydrothiazine derivative 公开/授权日:2012-06-12
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