发明申请
- 专利标题： Use of Inhibitors of Toll-Like Receptors in the Prevention and Treatment of Hypercholesterolemia and Hyperlipidemia and Diseases Related Thereto
- 专利标题（中）： 使用Toll样受体抑制剂预防和治疗高胆固醇血症和高脂血症及其相关疾病
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申请号： US12574576申请日： 2009-10-06
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公开(公告)号： US20100098685A1公开(公告)日： 2010-04-22
- 发明人: Fu-Gang Zhu , Ekambar Kandimalla , Sudhir Agrawal
- 申请人： Fu-Gang Zhu , Ekambar Kandimalla , Sudhir Agrawal
- 申请人地址： US MA Cambridge
- 专利权人： IDERA PHARMACEUTICALS, INC.
- 当前专利权人： IDERA PHARMACEUTICALS, INC.
- 当前专利权人地址： US MA Cambridge
- 主分类号： A61K39/395
- IPC分类号： A61K39/395 ; A61K31/711 ; A61K39/00 ; A61K31/4706 ; A61K31/7088 ; A61K38/45 ; A61K38/02 ; A61P9/10
摘要：
The invention provides the use of TLR inhibitors or a pharmaceutically acceptable derivative thereof, optionally in combination with one or more lipid lowering composition, cholesterol lowering composition, diuretics, non-steroidal anti-inflammatory compounds (NSAIDs), antibodies, antisense oligonucleotides, TLR agonists, TLR antagonists, peptides, proteins or gene therapy vectors or combinations thereof for the prevention or treatment of hypercholesterolemia and/or hyperlipidemia and/or diseases associated therewith.
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