发明申请
- 专利标题: PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR MODULATORS
- 专利标题(中): 过氧化物促进剂激活受体调节剂
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申请号: US12522723申请日: 2008-02-12
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公开(公告)号: US20100099725A1公开(公告)日: 2010-04-22
- 发明人: Lance Allen Pfeifer , Tianwei Ma , Nathan Bryan Mantlo , Laura Frey Michael , Fese Mambo Mokube , Chahrzad Montrose-Rafizadeh
- 申请人: Lance Allen Pfeifer , Tianwei Ma , Nathan Bryan Mantlo , Laura Frey Michael , Fese Mambo Mokube , Chahrzad Montrose-Rafizadeh
- 国际申请: PCT/US08/53653 WO 20080212
- 主分类号: A61K31/4196
- IPC分类号: A61K31/4196 ; C07D249/12 ; A61P9/10
摘要:
The present invention is directed to compounds of the structural Formula: wherein: R1 is H or —C1-C3 alkyl; R2 is selected from the group consisting of —H, —C1-C4 alkyl, —C1-C3 alkyl-CF3, phenyl, and pyridinyl; and R3 is selected from the group consisting of —H, —C1-C4 alkyl, —C1-C3 alkyl-O—CH3, —CH2-cyclopropyl, CH2—C═CH2, —CH2CH2-(2-F-phenyl), and phenyl substituted with from 1 to 2 fluorines; provided that when R1 and R2 are each H, then R3 is selected from the group consisting of —C1-C4 alkyl, —C1-C3 alkyl-O—CH3, —CH2-cyclopropyl, —CH2—C═CH2, —CH2CH2-(2-F-phenyl), and phenyl substituted with from 1 to 2 fluorines; or stereoisomers and pharmaceutically acceptable salts thereof.
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