发明申请
US20100099875A1 NEW ORTHO-FUNCTIONALIZED P-CHIRAL ARYLPHOSPHINES AND DERIVATIVES: THEIR PREPARATION AND USE IN ASYMMETRIC CATALYSIS
审中-公开
新型功能化的对甲苯磺酰胺和衍生物:其在不对称催化下的制备和使用
- 专利标题: NEW ORTHO-FUNCTIONALIZED P-CHIRAL ARYLPHOSPHINES AND DERIVATIVES: THEIR PREPARATION AND USE IN ASYMMETRIC CATALYSIS
- 专利标题(中): 新型功能化的对甲苯磺酰胺和衍生物:其在不对称催化下的制备和使用
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申请号: US11993408申请日: 2006-06-20
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公开(公告)号: US20100099875A1公开(公告)日: 2010-04-22
- 发明人: Michel Stephan , Barbara Mohar
- 申请人: Michel Stephan , Barbara Mohar
- 申请人地址: FR Paris SI Ljubljana
- 专利权人: PHOSPHOENIX SARL,NATIONAL INSTITUTE OF CHEMISTRY
- 当前专利权人: PHOSPHOENIX SARL,NATIONAL INSTITUTE OF CHEMISTRY
- 当前专利权人地址: FR Paris SI Ljubljana
- 优先权: FR0506226 20050620
- 国际申请: PCT/FR2006/001394 WO 20060620
- 主分类号: C07F9/02
- IPC分类号: C07F9/02 ; C07F9/28 ; C07F15/00 ; C07F1/00
摘要:
The invention relates to novel organo phosphorus P-chiral optically active compounds of formula (I) having a hydroxyl, mercapto, amino, carboxyl, sulfonyl group on aryl near a phosphorus atom, to the preparation and the use thereof in then asymmetrical catalysis of unsaturated compounds. Novel acylphosphine optically pure ligands embodied in the form of transition metal complexes exhibit an increased activity and enantloselectivity, in particular in asymmetrical hydrogenation, in comparison with the same type Uganda such as DiPAMP.