发明申请
US20100104501A1 PRSS23 AS A BIOMARKER, THERAPEUTIC AND DIAGNOSTIC TARGET
审中-公开
PRSS23作为生物标志物，治疗和诊断目标
- 专利标题： PRSS23 AS A BIOMARKER, THERAPEUTIC AND DIAGNOSTIC TARGET
- 专利标题（中）： PRSS23作为生物标志物，治疗和诊断目标
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申请号： US12445494申请日： 2007-10-02
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公开(公告)号： US20100104501A1公开(公告)日： 2010-04-29
- 发明人: Stefan Golz , Holger Summer , Andreas Geerts , Ulf Brüggemeier , Barbara Albrecht , Martina Klein , Sonja Steppan , Peter Ellinghaus , Donatella D'urso , Michael Seewald , Hendrik Milting
- 申请人： Stefan Golz , Holger Summer , Andreas Geerts , Ulf Brüggemeier , Barbara Albrecht , Martina Klein , Sonja Steppan , Peter Ellinghaus , Donatella D'urso , Michael Seewald , Hendrik Milting
- 优先权： EP06021606.6 20061016
- 国际申请： PCT/EP07/08562 WO 20071002
- 主分类号： A61K51/00
- IPC分类号： A61K51/00 ; C12Q1/68 ; G01N33/53 ; A61K49/00
摘要：
The invention provides PRSS23, which is associated with cardiovascular diseases, hematological diseases, neurological diseases, cancer, endocrinological diseases, and urological diseases. The invention also provides assays for the identification of compounds useful in the treatment or prevention of cardiovascular diseases, hematological diseases, neurological diseases, cancer, endocrinological diseases, and urological diseases. The invention also features compounds which bind to and/or activate or inhibit the activity of PRSS23 as well as pharmaceutical compositions comprising such compounds. The invention also provides PRSS23 as a biomarker for diseases such as cardiovascular diseases, hematological diseases, neurological diseases, cancer, endocrinological diseases, and urological diseases.