发明申请
US20100111935A1 Modulation of Toll-Like Receptor 2 Expression By Antisense Oligonucleotides
审中-公开
通过反义寡核苷酸调节Toll样受体2表达
- 专利标题： Modulation of Toll-Like Receptor 2 Expression By Antisense Oligonucleotides
- 专利标题（中）： 通过反义寡核苷酸调节Toll样受体2表达
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申请号： US12612370申请日： 2009-11-04
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公开(公告)号： US20100111935A1公开(公告)日： 2010-05-06
- 发明人: Lakshmi Bhagat , Ekambar Kandimalla , Mallikarjuna Putta , Daqing Wang , Dong Yu , Sudhir Agrawal
- 申请人： Lakshmi Bhagat , Ekambar Kandimalla , Mallikarjuna Putta , Daqing Wang , Dong Yu , Sudhir Agrawal
- 申请人地址： US MA Cambridge
- 专利权人： IDERA PHARMACEUTICALS, INC.
- 当前专利权人： IDERA PHARMACEUTICALS, INC.
- 当前专利权人地址： US MA Cambridge
- 主分类号： A61K48/00
- IPC分类号： A61K48/00 ; C07H21/02 ; A61P29/00 ; A61P11/00 ; A61P17/00 ; A61K39/395
摘要：
Antisense oligonucleotide compounds, compositions and methods are provided for down regulating the expression of TLR2. The compositions comprise antisense oligonucleotides targeted to nucleic acids encoding TLR2. The compositions may also comprise antisense oligonucleotides targeted to nucleic acids encoding TLR2 in combination with other therapeutic and/or prophylactic compounds and/or compositions. Methods of using these compounds and compositions for down-regulating TLR2 expression and for prevention or treatment of diseases wherein modulation of TLR2 expression would be beneficial are provided.
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