发明申请
US20100113448A1 OXAZOLIDINONE DERIVATIVE HAVING INHIBITORY ACTIVITY ON 11BETA-HYDROXYSTEROID DEHYDROGENASE TYPE 1
失效
在11BETA-羟基脱氢酶脱氢酶1型上具有抑制活性的奥沙利酮衍生物
- 专利标题: OXAZOLIDINONE DERIVATIVE HAVING INHIBITORY ACTIVITY ON 11BETA-HYDROXYSTEROID DEHYDROGENASE TYPE 1
- 专利标题(中): 在11BETA-羟基脱氢酶脱氢酶1型上具有抑制活性的奥沙利酮衍生物
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申请号: US12594093申请日: 2008-03-27
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公开(公告)号: US20100113448A1公开(公告)日: 2010-05-06
- 发明人: Akiko Itai , Susumu Muto , Ryuko Tokuyama , Hiroshi Fukasawa , Takeshi Yanase
- 申请人: Akiko Itai , Susumu Muto , Ryuko Tokuyama , Hiroshi Fukasawa , Takeshi Yanase
- 申请人地址: JP Tokyo JP Osaka-shi, Osaka
- 专利权人: INSTITUTE OF MEDICINAL MOLECULAR DESIGN, INC.,SHIONOGI & CO., LTD.
- 当前专利权人: INSTITUTE OF MEDICINAL MOLECULAR DESIGN, INC.,SHIONOGI & CO., LTD.
- 当前专利权人地址: JP Tokyo JP Osaka-shi, Osaka
- 优先权: JP2007-091023 20070330
- 国际申请: PCT/JP2008/055827 WO 20080327
- 主分类号: A61K31/421
- IPC分类号: A61K31/421 ; C07D413/12 ; C07D263/24 ; A61P3/10 ; A61K31/4439 ; A61K31/454 ; A61K31/5377 ; A61K31/496
摘要:
Disclosed is a compound which is useful as an 11β-hydroxysteroid dehydrogenase type 1 inhibitor.A compound represented by the formula: its pharmaceutically acceptable salt, or a solvate thereof, wherein R1 is optionally substituted cycloalkyl, optionally substituted cycloalkylalkyl, optionally substituted heterocycle or optionally substituted heterocyclealkyl, X is —O—, —NR3—, —NR3C(═O)— or —NR3S(═O)2—, R2 is optionally substituted aryl, optionally substituted arylalkyl, optionally substituted heteroaryl or optionally substituted heteroarylalkyl, R3 is hydrogen or optionally substituted alkyl.