发明申请
- 专利标题： AMIDE COMPOUNDS AND THEIR USE AS ANTITUMOR AGENTS
- 专利标题（中）： AMIDE化合物及其作为抗菌剂使用
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申请号： US12528912申请日： 2008-03-12
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公开(公告)号： US20100113504A1公开(公告)日： 2010-05-06
- 发明人: Stephan Hanessian , Luciana Auzzas , Giuseppe Giannini , Claudio Pisano , Loredana Vesci , Walter Cabri
- 申请人： Stephan Hanessian , Luciana Auzzas , Giuseppe Giannini , Claudio Pisano , Loredana Vesci , Walter Cabri
- 申请人地址： IT Roma
- 专利权人： SIGMA-TAU INDUSTRIE FARMACEUTICHE RIUNITE S.P.A.
- 当前专利权人： SIGMA-TAU INDUSTRIE FARMACEUTICHE RIUNITE S.P.A.
- 当前专利权人地址： IT Roma
- 优先权： EP07104071.1 20070313
- 国际申请： PCT/EP08/52965 WO 20080312
- 主分类号： A61K31/4353
- IPC分类号： A61K31/4353 ; C07C233/00 ; C07D273/01 ; C07D273/02 ; C07D498/04 ; A61K31/16 ; A61K31/395 ; A61K31/4162 ; A61K31/407 ; A61P35/04
摘要：
The present invention relates to a compound of Formula (I), its geometrical isomers, in an optically active form as enantiomers, diastereomers, as well as in the form of racemate, as well as pharmaceutically acceptable salts thereof, wherein R is selected from CONHOH, CONHCH2SH, CONHCH2SCOCH3, SH, SCOCH3, SCH3, N(OH)COH, COCONHCH3 and CF3 for the preparation of a medicament, in particular for selectively inducing terminal differentiation of neoplastic cells and thereby inhibiting proliferation of such cells, for inducing differentiation of tumor cells in a tumor, for inhibiting the activity of histone deacetylase and for the treatment of primary cancer or secondary cancer.
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