发明申请
US20100120785A1 2-[4-(PYRAZOL-4-YLALKYL)PIPERAZIN-1-YL]-3-PHENYL PYRAZINES AND PYRIDINES AND 3-[4-(PYRAZOL-4-YLALKYL)PIPERAZIN-1-YL]-2-PHENYL PYRIDINES AS 5-HT7 RECEPTOR ANTAGONISTS
有权
2- [4-（吡唑-4-基）乙基]哌嗪-1-基] -3-苯基吡咯并吡啶和3- [4-（吡唑-4-基）乙基]哌嗪-1-基] -2-苯基吡啶 5-HT7受体拮抗剂
![2-[4-(PYRAZOL-4-YLALKYL)PIPERAZIN-1-YL]-3-PHENYL PYRAZINES AND PYRIDINES AND 3-[4-(PYRAZOL-4-YLALKYL)PIPERAZIN-1-YL]-2-PHENYL PYRIDINES AS 5-HT7 RECEPTOR ANTAGONISTS](/docs/US/2010-05-13/US20100120785A1/abs.jpg.600x600.jpg)
- 专利标题： 2-[4-(PYRAZOL-4-YLALKYL)PIPERAZIN-1-YL]-3-PHENYL PYRAZINES AND PYRIDINES AND 3-[4-(PYRAZOL-4-YLALKYL)PIPERAZIN-1-YL]-2-PHENYL PYRIDINES AS 5-HT7 RECEPTOR ANTAGONISTS
- 专利标题（中）： 2- [4-（吡唑-4-基）乙基]哌嗪-1-基] -3-苯基吡咯并吡啶和3- [4-（吡唑-4-基）乙基]哌嗪-1-基] -2-苯基吡啶 5-HT7受体拮抗剂
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申请号： US12597255申请日： 2008-05-07
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公开(公告)号： US20100120785A1公开(公告)日： 2010-05-13
- 发明人: Valentina O. Badescu , Anne Marie Camp , Barry Peter Clark , Michael Philip Cohen , Sandra Ann Filla , Peter Thaddeus Gallagher , Sarah Lynne Hellman , Michael Philip Mazanetz , Marta Maria Pineiro-Nunez , John Mehnert Schaus , Patrick Gianpietro Spinazze , Maria Ann Whatton
- 申请人： Valentina O. Badescu , Anne Marie Camp , Barry Peter Clark , Michael Philip Cohen , Sandra Ann Filla , Peter Thaddeus Gallagher , Sarah Lynne Hellman , Michael Philip Mazanetz , Marta Maria Pineiro-Nunez , John Mehnert Schaus , Patrick Gianpietro Spinazze , Maria Ann Whatton
- 申请人地址： US IN Indianapolis
- 专利权人： ELI LILLY AND COMPANY
- 当前专利权人： ELI LILLY AND COMPANY
- 当前专利权人地址： US IN Indianapolis
- 国际申请： PCT/US08/62834 WO 20080507
- 主分类号： A61K31/497
- IPC分类号： A61K31/497 ; C07D241/02 ; A61P25/06
![2-[4-(PYRAZOL-4-YLALKYL)PIPERAZIN-1-YL]-3-PHENYL PYRAZINES AND PYRIDINES AND 3-[4-(PYRAZOL-4-YLALKYL)PIPERAZIN-1-YL]-2-PHENYL PYRIDINES AS 5-HT7 RECEPTOR ANTAGONISTS](/abs-image/US/2010/05/13/US20100120785A1/abs.jpg.150x150.jpg)
摘要：
The present invention provides selective 5-HT7 receptor antagonist compounds of Formula I and their use in the treatment of migraine, persistent pain, and anxiety: where A and B are each independently C(H)═ or N═, provided that at least one of A and B is —N═, n is 1-3, m is 0-3, and R14 are as defined herein.
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