发明申请
US20100120901A1 NOVEL COMPOUNDS, PHARMACEUTICAL COMPOSITIONS CONTAINING SAME, AND METHODS OF USE FOR SAME
审中-公开
新化合物，含有该化合物的药物组合物及其使用方法
- 专利标题： NOVEL COMPOUNDS, PHARMACEUTICAL COMPOSITIONS CONTAINING SAME, AND METHODS OF USE FOR SAME
- 专利标题（中）： 新化合物，含有该化合物的药物组合物及其使用方法
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申请号： US12686691申请日： 2010-01-13
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公开(公告)号： US20100120901A1公开(公告)日： 2010-05-13
- 发明人: Francis P. Kuhajda , Susan M. Medghalchi , Jill M. McFadden , Jagan Thupari , Craig A. Townsend
- 申请人： Francis P. Kuhajda , Susan M. Medghalchi , Jill M. McFadden , Jagan Thupari , Craig A. Townsend
- 申请人地址： US MD Baltimore US MD Baltimore
- 专利权人： FASGEN,INC,THE JOHNS HOPKINS UNIVERSITY
- 当前专利权人： FASGEN,INC,THE JOHNS HOPKINS UNIVERSITY
- 当前专利权人地址： US MD Baltimore US MD Baltimore
- 主分类号： A61K31/381
- IPC分类号： A61K31/381 ; C07D333/32 ; A61P3/00 ; A61P31/00
摘要：
A pharmaceutical composition comprising a pharmaceutical diluent and a compound of formula IV wherein R21=H, C1-C20 alkyl, cycloalkyl, alkenyl, aryl, arylalkyl, or alkylaryl, —CH2OR25, —C(O)R25, —CO(O)R25, —C(O)NR25R26, —CH2C(O)R25, or —CH2C(O)NHR25, where R25 and R26 are each independently H, C1-C10 alkyl, cycloalkyl, alkenyl, aryl, arylalkyl, or alkylaryl, optionally containing one or more halogen atoms. R22=—OH, —OR27, —OCH2C(O)R27, —OCH2C(O)NHR27, —OC(O)R27, —OC(O)OR27, —OC(O)NHNH—R5, or —OC(O)NR27R28, where R27 and R28 are each independently H, C1-C20 alkyl, cycloalkyl, alkenyl, aryl, arylalkyl, or alkylaryl, and where R27 and R28 can each optionally contain halogen atoms; R23 and R24, the same or different from each other, are C1-C20 alkyl, cycloalkyl, alkenyl, aryl, arylalkyl, or alkylaryl. Methods of using such formulations for the treatment of cancer, to effect weight loss, to treat microbially-based infections, to inhibit neuropeptide-Y and/or fatty acid synthase, and to stimulate CPT-1.