A device for sensing a physiological signal comprises: two sensing units connected to the palms a subject respectively to receive a first electrocardiogram (ECG) signal; a filter for generating a second ECG signal by filtering the first ECG signal; an amplifying unit for generating a third ECG signal by amplifying the second ECG signal; an analog to digital converting unit for converting the third ECG signal into a digital signal; an operating unit for generating a plurality of analysis data by operationally analyzing the digital signal; and a display unit for displaying the plurality of analysis data. Therefore, the accuracy of the ECG is improved and the operation is simplified.