发明申请
US20100130482A1 DIAZABICYCLIC ARYL DERIVATIVES AS NICOTINIC ACETYLCHOLINE RECEPTOR LIGANDS
审中-公开
作为NICOTINIC乙酰胆碱受体配体的二亚氨基衍生物
- 专利标题： DIAZABICYCLIC ARYL DERIVATIVES AS NICOTINIC ACETYLCHOLINE RECEPTOR LIGANDS
- 专利标题（中）： 作为NICOTINIC乙酰胆碱受体配体的二亚氨基衍生物
-
申请号： US12652512申请日： 2010-01-05
-
公开(公告)号： US20100130482A1公开(公告)日： 2010-05-27
- 发明人: Dan Peters , Gunnar M. Olsen , Elsebet Østergaard Nielsen , Tino Dyhring Jørgensen , Philip K. Ahring , Daniel B. Timmerman
- 申请人： Dan Peters , Gunnar M. Olsen , Elsebet Østergaard Nielsen , Tino Dyhring Jørgensen , Philip K. Ahring , Daniel B. Timmerman
- 优先权： DKPA200400169 20040204; DKPA200400839 20040528
- 主分类号： A61K31/5513
- IPC分类号： A61K31/5513 ; C07D243/10 ; A61P25/28 ; A61P25/30 ; A61P25/18 ; A61P25/24
摘要：
This invention relates to novel diazabicyclic aryl derivatives which are found to be cholinergic ligands at the nicotinic acetylcholine receptors. Due to their pharmacological profile the compounds of the invention may be useful for the treatment of diseases or disorders as diverse as those related to the cholinergic system of the central nervous system (CNS), the peripheral nervous system (PNS), diseases or disorders related to smooth muscle contraction, endocrine diseases or disorders, diseases or disorders related to neuro-degeneration, diseases or disorders related to inflammation, pain, and withdrawal symptoms caused by the termination of abuse of chemical substances.