发明申请
US20100130523A1 MONO-HYDROCHLORIC SALTS OF AN INHIBITOR OF HISTONE DEACETYLASE
审中-公开
甲基脱乙酰壳多糖抑制剂的单盐酸盐
- 专利标题: MONO-HYDROCHLORIC SALTS OF AN INHIBITOR OF HISTONE DEACETYLASE
- 专利标题(中): 甲基脱乙酰壳多糖抑制剂的单盐酸盐
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申请号: US12598743申请日: 2008-05-13
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公开(公告)号: US20100130523A1公开(公告)日: 2010-05-27
- 发明人: Julius W.J. Dickens , Ioannes Nicolaos Houpis , Yolande Lydia Lang , Carina Leys , Sigrid Carl Maria Stokbroekx , Johan Erwin Edmond Weerts
- 申请人: Julius W.J. Dickens , Ioannes Nicolaos Houpis , Yolande Lydia Lang , Carina Leys , Sigrid Carl Maria Stokbroekx , Johan Erwin Edmond Weerts
- 优先权: EP07108176.4 20070514
- 国际申请: PCT/EP08/55804 WO 20080513
- 主分类号: A61K31/506
- IPC分类号: A61K31/506 ; C07D211/28 ; C07D401/14 ; A61P35/00 ; A61P35/02
摘要:
This invention provides novel crystalline forms of mono-HCl salts and a mono-HCl salt hydrate of JNJ-26481585, an inhibitor of histone deacetylases. The invention also relates to processes for production of these forms, to intermediates used in these processes, to pharmaceutical compositions comprising these forms, and to the use of these forms in medical treatment for instance as a medicine to inhibit proliferative conditions, such as cancer and leukemia.
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