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发明申请
US20100130592A1 RNA Interference Mediated Inhibition of GRB2 Associated Binding Protein (GAB2) Gene Expression Using Short Interfering Nucleic Acid (siNA) 有权
RNA干扰介导的使用短干扰核酸（siNA）的GRB2相关结合蛋白（GAB2）基因表达的抑制

RNA Interference Mediated Inhibition of GRB2 Associated Binding Protein (GAB2) Gene Expression Using Short Interfering Nucleic Acid (siNA)
摘要：
This invention relates to compounds, compositions, and methods useful for modulating GRB2 associated binding protein (GAB2) gene expression using short interfering nucleic acid (siNA) molecules. This invention also relates to compounds, compositions, and methods useful for modulating the expression and activity of other genes involved in pathways of GRB2 associated binding protein (GAB2) gene expression and/or activity by RNA interference (RNAi) using small nucleic acid molecules. In particular, the instant invention features small nucleic acid molecules, such as short interfering nucleic acid (siNA), short interfering RNA (siRNA), double-stranded RNA (dsRNA), micro-RNA (miRNA), and short hairpin RNA (shRNA) molecules and methods used to modulate the expression of GAB2 genes. The small nucleic acid molecules are useful in the treatment of cancer, malignant blood disease (leukemia), inflammatory diseases or conditions, allergic diseases or conditions, or proliferative diseases or conditions.
摘要（中）：

本发明涉及使用短干扰核酸（siNA）分子调节GRB2相关结合蛋白（GAB2）基因表达的化合物，组合物和方法。 本发明还涉及使用小核酸分子调节参与GRB2相关结合蛋白（GAB2）基因表达和/或通过RNA干扰（RNAi）的活性的其他基因的表达和活性的化合物，组合物和方法。 特别地，本发明的特征在于小核酸分子，例如短干扰核酸（siNA），短干扰RNA（siRNA），双链RNA（dsRNA），微RNA（miRNA）和短发夹RNA（shRNA） ）分子和用于调节GAB2基因表达的方法。 小核酸分子可用于治疗癌症，恶性血液病（白血病），炎性疾病或病症，过敏性疾病或病症，或增殖性疾病或病症。

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