发明申请
- 专利标题： POLYMERIC CARRIER FOR DELIVERY OF SMALL INTERFERING RNA
- 专利标题（中）： 用于递送小干扰RNA的聚合载体
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申请号： US12691566申请日： 2010-01-21
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公开(公告)号： US20100130722A1公开(公告)日： 2010-05-27
- 发明人: Won Jong Kim , Sung Wan Kim
- 申请人： Won Jong Kim , Sung Wan Kim
- 申请人地址： US UT Salt Lake City
- 专利权人： UNIVERSITY OF UTAH RESEARCH FOUNDATION
- 当前专利权人： UNIVERSITY OF UTAH RESEARCH FOUNDATION
- 当前专利权人地址： US UT Salt Lake City
- 主分类号： C07K7/06
- IPC分类号： C07K7/06 ; C07K7/08 ; C07K5/11
摘要：
A carrier for delivering small interfering RNA (siRNA) into cells includes a cholesterol residue covalently bonded to oligoarginine. Mixing the siRNA with the carrier produces a complex-containing composition. Contacting a cell with the complex-containing composition results in delivery of the siRNA into the cell. Delivery of an siRNA targeted to vascular endothelial growth factor is a treatment for cancer. Methods of making the carrier and complex are also disclosed.
公开/授权文献
- US08058256B2 Polymeric carrier for delivery of small interfering RNA 公开/授权日：2011-11-15
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