Systems and methods for providing adaptive, work-centered healthcare services via an adaptive user interface are provided. An example adaptive user interface apparatus includes a plurality of widgets providing applications and/or data to a user based on a particular data context, the plurality of widgets responsive to input from the user. The apparatus also includes a query engine providing customized query results from a connectivity framework of data sources based on a user query and the particular data context. The apparatus further includes a user interface display area configurable by the user to position widget(s) and query engine access to enable the user to access, input, and search medical information across a healthcare enterprise. The user interface includes an adaptive, work-centered interface employing an ontology modeling approach to characterize the user's workspace based on workflow activities and computation mechanisms to support the user's workflow and access to enterprise applications and data.