The present invention provides a manufacturing method of three-dimensional cross-linked foam for uppers of shoes that comprises preparing plural foaming materials having a planar shape with the cross-linked foaming suppressed; forming at least one interfacing pattern including a main interfacing pattern on at least one of the foaming materials; cross-linked foaming the foaming material to obtain a planar cross-linked foam having at least one inner cavity structure including a main inner cavity structure, the main inner cavity structure formed by the main interfacing pattern; cutting a portion of a contour of the main inner cavity structure to expose the main inner cavity structure; putting a last into the exposed main inner cavity structure and disposing the cross-linked foam in a cavity of a molding die together with the last; and compression molding the disposed cross-linked foam after closing the molding die, inner and outer surfaces of the cross-linked foam formed in shapes corresponding to an outer surface of the last and a surface of the cavity of the molding die, respectively.