发明申请
- 专利标题： Interferon Alpha Receptor I Antibodies And Their Use
- 专利标题（中）： 干扰素α受体I抗体及其用途
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申请号： US12704948申请日： 2010-02-12
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公开(公告)号： US20100143369A1公开(公告)日： 2010-06-10
- 发明人: Josephine M. Cardarelli , Alison Witte , Mohan Srinivasan
- 申请人： Josephine M. Cardarelli , Alison Witte , Mohan Srinivasan
- 主分类号： A61K39/395
- IPC分类号： A61K39/395 ; A61P37/06
摘要：
The present invention provides isolated human monoclonal antibodies that bind to IFNAR-1 and that are capable of inhibiting the biological activity of Type I interferons. Immunoconjugates, bispecific molecules and pharmaceutical compositions comprising the antibodies of the invention are also provided. The invention also provides methods for inhibiting Type I interferon-mediated disorders using the antibodies of the invention, including methods for treating autoimmune disorders, transplant rejection or Graft Versus Host Disease using the antibodies of the invention.
公开/授权文献
- US08460668B2 Interferon alpha receptor I antibodies and their use 公开/授权日：2013-06-11