发明申请
- 专利标题: ANGIOTENSIN II RECEPTOR ANTAGONISTS
- 专利标题(中): ANGIOTENSIN II受体拮抗剂
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申请号: US12629419申请日: 2009-12-02
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公开(公告)号: US20100144810A1公开(公告)日: 2010-06-10
- 发明人: Michael Man-Chu Lo , Amjad Ali , Ravi P. Nargund
- 申请人: Michael Man-Chu Lo , Amjad Ali , Ravi P. Nargund
- 主分类号: A61K31/4178
- IPC分类号: A61K31/4178 ; C07D403/10 ; C07D257/04 ; C07D409/06 ; A61K31/41 ; A61K31/4184 ; A61P9/12
摘要:
A compound having the structure wherein R is an angiotensin receptor antagonist active group, and Y is Y is selected from the group consisting of R1 is selected from the group consisting of —O—C1-6 alkyl, —O-aryl, —O-heteroaryl, —O—C3-8 cycloalkyl, —C1-6 alkyl, -aryl, -heteroaryl, and —C3-8 cycloalkyl; R2 and R3 are independently selected from the group consisting of hydrogen and C1-4 alkyl, or a pharmaceutically acceptable salt or hydrate thereof, which is useful for treating hypertension.
公开/授权文献
- US08293777B2 Angiotensin II receptor antagonists 公开/授权日:2012-10-23