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发明申请
US20100144842A1 RNA Interference Mediated Inhibition of NOGO and NOGO Receptor Gene Expression Using Short Interfering Nucleic Acid (siNA) 有权
RNA干扰介导的使用短干扰核酸（siNA）的NOGO和NOGO受体基因表达的抑制

RNA Interference Mediated Inhibition of NOGO and NOGO Receptor Gene Expression Using Short Interfering Nucleic Acid (siNA)
摘要：
This invention relates to compounds, compositions, and methods useful for modulating NOGO and/or NOGO receptor gene expression using short interfering nucleic acid (siNA) molecules. This invention also relates to compounds, compositions, and methods useful for modulating the expression and activity of other genes involved in pathways of NOGO and/or NOGO receptor gene expression and/or activity by RNA interference (RNAi) using small nucleic acid molecules. In particular, the instant invention features small nucleic acid molecules, such as short interfering nucleic acid (siNA), short interfering RNA (siRNA), double-stranded RNA (dsRNA), micro-RNA (miRNA), and short hairpin RNA (shRNA) molecules and methods used to modulate the expression of NOGO and/or NOGO receptor genes, such as NOGO-A, NOGO-B, NOGO-C, NOGO-66 receptor, NI-35, NI-220, NI-250, myelin-associated glycoprotein, tenascin-R, and NG-2
摘要（中）：

本发明涉及使用短干扰核酸（siNA）分子调节NOGO和/或NOGO受体基因表达的化合物，组合物和方法。 本发明还涉及可用于通过使用小核酸分子调节参与NOGO和/或NOGO受体基因表达和/或通过RNA干扰（RNAi）的活性的其它基因的表达和活性的化合物，组合物和方法。 特别地，本发明的特征在于小核酸分子，例如短干扰核酸（siNA），短干扰RNA（siRNA），双链RNA（dsRNA），微RNA（miRNA）和短发夹RNA（shRNA） ）分子和用于调节NOGO和/或NOGO受体基因如NOGO-A，NOGO-B，NOGO-C，NOGO-66受体，NI-35，NI-220，NI-250，髓磷脂 相关糖蛋白，腱生蛋白-R和NG-2

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