发明申请
- 专利标题: Process for Producing Cyclic Compounds
- 专利标题(中): 生产环状化合物的方法
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申请号: US12702818申请日: 2010-02-09
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公开(公告)号: US20100145072A1公开(公告)日: 2010-06-10
- 发明人: Todd A. Werpy , John G. Frye, JR. , James F. White , Johnathan E. Holladay , Alan H. Zacher
- 申请人: Todd A. Werpy , John G. Frye, JR. , James F. White , Johnathan E. Holladay , Alan H. Zacher
- 申请人地址: US WA Richland
- 专利权人: BATTELLE MEMORIAL INSTITUTE
- 当前专利权人: BATTELLE MEMORIAL INSTITUTE
- 当前专利权人地址: US WA Richland
- 主分类号: C07D207/408
- IPC分类号: C07D207/408 ; C07D207/267
摘要:
The invention includes methods of processing an initial di-carbonyl compound by conversion to a cyclic compound. The cyclic compound is reacted with an alkylating agent to form a derivative having an alkylated ring nitrogen. The invention encompasses a method of producing an N-alkyl product. Ammonia content of a solution is adjusted to produce a ratio of ammonia to di-carboxylate compound of from about 1:1 to about 1.5:1. An alkylating agent is added and the initial compound is alkylated and cyclized. The invention includes methods of making N-methylpyrrolidinone (NMP). Aqueous ammonia and succinate is introduced into a vessel and ammonia is adjusted to provide a ratio of ammonia to succinate of less than 2:1. A methylating agent is reacted with succinate at a temperature of from greater than 100° C. to about 400° C. to produce N-methyl succinimide which is purified and hydrogenated to form NMP.
公开/授权文献
- US07973177B2 Process for producing cyclic compounds 公开/授权日:2011-07-05