Devices, systems and methods are disclosed for selecting and sending one of a plurality of responses to a call on a communications device. A user may select a default response or a custom response. When the user receives a call to a communications device, a set of responses is displayed on the communications device to facilitate selection by the user. A response includes a message and a call processing command. A message is in the form of an audio clip, text message, webpage, picture, video, etc. A call processing command, such as “accept call”; “reject call with voicemail”; “reject call without voicemail”; “place caller on hold”; “forward call to 555-555-5555”; “I will call you back”; etc. is performed along with the message. This plurality of responses can be organized by the user in groups associated with classes of callers, such as friends, family, co-workers, etc. In this manner, the responses available to the user when a call is received changes depending on the caller.