发明申请
US20100151576A1 TARGETED TUMOR THERAPY BY USE OF RECOMBINANT ADENOVIRUS VECTORS THAT SELECTIVELY REPLICATE IN HYPOXIC REGIONS OF TUMORS
审中-公开
通过使用重组腺病毒载体的靶向肿瘤治疗方法，其可选择性地替代肿瘤的高血压地区
- 专利标题： TARGETED TUMOR THERAPY BY USE OF RECOMBINANT ADENOVIRUS VECTORS THAT SELECTIVELY REPLICATE IN HYPOXIC REGIONS OF TUMORS
- 专利标题（中）： 通过使用重组腺病毒载体的靶向肿瘤治疗方法，其可选择性地替代肿瘤的高血压地区
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申请号： US12708866申请日： 2010-02-19
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公开(公告)号： US20100151576A1公开(公告)日： 2010-06-17
- 发明人: Chuan-Yuan Li , Qian Huang , Mark W. Dewhirst
- 申请人： Chuan-Yuan Li , Qian Huang , Mark W. Dewhirst
- 主分类号： C12N15/861
- IPC分类号： C12N15/861
摘要：
The presently claimed subject matter provides conditionally replication competent adenoviral vectors that confer selective cytotoxicity on cells expressing HIF-1 by infecting cells that allow HIF-1 inducible promoters present within the vectors to function. Also provided are compositions and host cells based upon the vectors, as well as methods of propagating and using the vectors. The presently claimed subject matter further provides a method of inhibiting tumor growth by co-infecting cells in a tumor with a conditionally replication competent adenovirus vector in conjunction with a replication deficient adenovirus vector.
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