发明申请
- 专利标题： MONOCYCLIC ANILIDE SPIROLACTAM CGRP RECEPTOR ANTAGONISTS
- 专利标题（中）： 单克隆抗炎螺旋体CGRP受体拮抗剂
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申请号： US12530898申请日： 2008-03-07
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公开(公告)号： US20100152216A1公开(公告)日： 2010-06-17
- 发明人: Craig A. Stump , Ian M. Bell , Harold G. Selnick
- 申请人： Craig A. Stump , Ian M. Bell , Harold G. Selnick
- 国际申请： PCT/US08/03078 WO 20080307
- 主分类号： A61K31/513
- IPC分类号： A61K31/513 ; C07D403/12 ; A61K31/4184 ; C07D471/10 ; A61K31/437 ; A61P25/06 ; C07D491/107 ; C07D471/20
摘要：
The present invention is directed to compounds of Formula I: (where variables A1, A2, B, J, K, m, n, R4, R5a, R5b and R5c are as defined herein) useful as antagonists of CGRP receptors and useful in the treatment or prevention of diseases in which the CGRP is involved, such as headache, migraine and cluster headache. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which CGRP is involved.
公开/授权文献
- US08148390B2 Monocyclic anilide spirolactam CGRP receptor antagonists 公开/授权日：2012-04-03
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