Provided are a flexible waveguide structure and an optical interconnection assembly. The flexible waveguide structure includes a thin film strip core, an inner cladding layer, and an outer cladding layer. The thin film strip core has opposed first and second surfaces and is formed of a metal. The inner cladding layer covers at least one of the first and second surfaces of the thin film strip core. The outer cladding layer covers the inner cladding layer. The inner cladding layer has a refractive index higher than that of the outer cladding layer.