发明申请
US20100168174A1 Combination of AMPA Receptor Antagonists and Acetylcholinesterase Inhibitors for the Treatment of Neuropathic Pain
审中-公开
AMPA受体拮抗剂和乙酰胆碱酯酶抑制剂联合治疗神经性疼痛
- 专利标题： Combination of AMPA Receptor Antagonists and Acetylcholinesterase Inhibitors for the Treatment of Neuropathic Pain
- 专利标题（中）： AMPA受体拮抗剂和乙酰胆碱酯酶抑制剂联合治疗神经性疼痛
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申请号： US12663550申请日： 2008-07-11
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公开(公告)号： US20100168174A1公开(公告)日： 2010-07-01
- 发明人: Takahisa Hanada
- 申请人： Takahisa Hanada
- 申请人地址： JP Tokyo
- 专利权人： Eisai R&D Management Co., Ltd.
- 当前专利权人： Eisai R&D Management Co., Ltd.
- 当前专利权人地址： JP Tokyo
- 国际申请： PCT/JP2008/062976 WO 20080711
- 主分类号： A61K31/444
- IPC分类号： A61K31/444 ; A61P25/00
摘要：
The invention provides methods for treating and/or preventing neuropathic pain by administering to patients in need thereof therapeutically effective amounts of AMPA receptor antagonists; and cholinesterase inhibitors and/or anti-neuropathic pain agents. The neuropathic pain may be painful diabetic neuropathy. The invention also provides kits, and pharmaceutical compositions comprising therapeutically effective amounts of AMPA receptor antagonists; and cholinesterase inhibitors and/or anti-neuropathic pain agents. The AMPA receptor antagonists may be, for example, 3-(2-cyanophenyl)-5-(2-pyridyl)-1-phenyl-1,2-dihydropyridin-2-one. The cholinesterase inhibitor may be, for example, 1-benzyl-4-((5,6-dimethoxy-1-indanon)-2-yl)methylpiperidine (donepezil).
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