发明申请
- 专利标题: Novel Compounds
- 专利标题(中): 新型化合物
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申请号: US12478587申请日: 2009-06-04
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公开(公告)号: US20100168180A1公开(公告)日: 2010-07-01
- 发明人: Gerard Andrew Potter , Philip Huxley
- 申请人: Gerard Andrew Potter , Philip Huxley
- 优先权: GBGB0810228.7 20080604
- 主分类号: A61K31/443
- IPC分类号: A61K31/443 ; C07D213/64 ; A61K31/4418 ; C07D405/10 ; A61P35/00
摘要:
A compound for use in the treatment of proliferative disorders, such as cancer, having the following formula: wherein: R1, R2 and R3 are independently H or lower alkyl; R4, R5, R6, R7 and R8 are independently H, halo, lower alkyl or —O-lower alkyl, provided that at least one is —O-lower alkyl; or at least one pair of R4 to R8, the members of which pair are adjacent to one another on the ring, are conjoined to form —O—(CR14R15)n—O—, where n is 1 or 2 and R14 and R15 are independently H or lower alkyl, and the remainder of R4 to R8 are independently H, halo, lower alkyl or —O-lower alkyl; and R9, R10, R11, R12 and R13 are independently H, halo, lower alkyl or —O— lower alkyl, provided that at least one is —O-lower alkyl; or at least one pair of R9 to R13, the members of which pair are adjacent to one another on the ring, are conjoined to form —O—(CR16R17)m—O—, where m is 1 or 2 and R16 and R17 are independently H or lower alkyl, and the remainder of R9 to R13 are independently H, halo, lower alkyl or —O-lower alkyl.
公开/授权文献
- US08236827B2 Compounds 公开/授权日:2012-08-07
信息查询
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