发明申请
US20100172968A1 CHIMERIC CANNULAE PROTEINS AND METHODS FOR MAKING AND USING THEM
审中-公开
CHIMERIC CANNULAE蛋白质及其制备和使用方法
- 专利标题: CHIMERIC CANNULAE PROTEINS AND METHODS FOR MAKING AND USING THEM
- 专利标题(中): CHIMERIC CANNULAE蛋白质及其制备和使用方法
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申请号: US11929781申请日: 2007-10-30
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公开(公告)号: US20100172968A1公开(公告)日: 2010-07-08
- 发明人: Jay Short , Eric J. Mathur , W. Michael Lafferty , Nelson Barton , Kevin Chow
- 申请人: Jay Short , Eric J. Mathur , W. Michael Lafferty , Nelson Barton , Kevin Chow
- 主分类号: A61K9/48
- IPC分类号: A61K9/48 ; A61K9/10 ; C12N15/63 ; C07K14/00 ; C07K16/00
摘要:
A polymer is prepared by self-assembly of a plurality of monomeric polypeptide units. The polymer tends to form a nanotube and is capable of encapsulating a particular drug molecule. Once encapsulated in the polymer of the present invention, the drug molecule may be delivered to a particular location of human body to effectively cure a disease or treat a symptom.Generally, the monomeric polypeptide unit of the present invention has a sequence found in Pyrodictium abyssi, a microorganism that produces an extracellular network having hollow protein tubes, or a sequence substantially identical thereto. The monomeric polypeptide may be mass produced using recombinant biotechnologies and be polymerized into the polymer of the present invention. One or more additional targeting vector may be attached to the monomeric polypeptide unit or the polymer to facilitate the targeting of the drug molecule that may be held there within. The sequence contained in the monomeric polypeptide unit may be further optimized using one or more technique selected from Gene Site Saturation Mutagenesis and GeneReasembly.