发明申请
US20100173841A1 Highly Purified Type A Botulinum Toxin Preparation From Infant Botulism Pathogen
有权
高纯度A型肉毒杆菌毒素从婴儿肉毒杆菌病原体制备
- 专利标题： Highly Purified Type A Botulinum Toxin Preparation From Infant Botulism Pathogen
- 专利标题（中）： 高纯度A型肉毒杆菌毒素从婴儿肉毒杆菌病原体制备
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申请号： US12447351申请日： 2007-10-26
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公开(公告)号： US20100173841A1公开(公告)日： 2010-07-08
- 发明人: Tetsuhiro Harakawa , Hirotoshi Nakano , Yasushi Torii , Yoshitaka Goto , Miho Shinmura , Sachio Okuda , Ryuji Kaji , Shunji Kosaki
- 申请人： Tetsuhiro Harakawa , Hirotoshi Nakano , Yasushi Torii , Yoshitaka Goto , Miho Shinmura , Sachio Okuda , Ryuji Kaji , Shunji Kosaki
- 申请人地址： JP Kumamoto-shi, Kumamoto-ken
- 专利权人： Juridical Foundation the Chemo-Sero-Therapeutic Research Institute
- 当前专利权人： Juridical Foundation the Chemo-Sero-Therapeutic Research Institute
- 当前专利权人地址： JP Kumamoto-shi, Kumamoto-ken
- 优先权： JP2006-293173 20061027
- 国际申请： PCT/JP2007/070927 WO 20071026
- 主分类号： A61K38/16
- IPC分类号： A61K38/16 ; C07K14/33 ; A61P25/06 ; A61P13/10 ; A61P25/14 ; A61P25/00 ; A61P21/00 ; A61P29/00
摘要：
A novel type A botulinum toxin preparation is provided. A neuromuscular transmission blocking agent comprising as an active ingredient a highly purified type A botulinum toxin from Clostridium botulinum as infant botulism pathogen and a medicament for treating a disease with a muscle overactivity comprising as an active ingredient said toxin. In particular, the medicament of the present invention, as compared to the conventional known botulinum toxin preparations, has rapid efficacy of potential and is less diffusive and thus, having a broader safety margin, may be used as therapeutic medicament for decreasing local, muscle overactivity in a disease with a muscle overactivity.
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