发明申请
US20100174101A1 Process for the manufacture of 7-alpha-[9-(4,4,5,5,5-penta fluoropentylsulphinyl) nonyl]estra-1,3,5-(10)- triene-3,17-beta-diol
审中-公开
7-α-[9-（4,4,5,5,5-五氟戊基亚磺酰基）壬基]雌-1,3,5-（10） - 三烯-3,17-β-二醇的制备方法
![Process for the manufacture of 7-alpha-[9-(4,4,5,5,5-penta fluoropentylsulphinyl) nonyl]estra-1,3,5-(10)- triene-3,17-beta-diol](/docs/US/2010-07-08/US20100174101A1/abs.jpg.600x600.jpg)
- 专利标题： Process for the manufacture of 7-alpha-[9-(4,4,5,5,5-penta fluoropentylsulphinyl) nonyl]estra-1,3,5-(10)- triene-3,17-beta-diol
- 专利标题（中）： 7-α-[9-（4,4,5,5,5-五氟戊基亚磺酰基）壬基]雌-1,3,5-（10） - 三烯-3,17-β-二醇的制备方法
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申请号： US12532444申请日： 2007-09-24
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公开(公告)号： US20100174101A1公开(公告)日： 2010-07-08
- 发明人: Suoding Cao , Yuanlin Zhou , Yaping Shen , Tao Chen
- 申请人： Suoding Cao , Yuanlin Zhou , Yaping Shen , Tao Chen
- 申请人地址： CN Shaanxi
- 专利权人： XI'AN LIBAND PHARMACEUTICAL CO., LTD.
- 当前专利权人： XI'AN LIBAND PHARMACEUTICAL CO., LTD.
- 当前专利权人地址： CN Shaanxi
- 国际申请： PCT/CN2007/070760 WO 20070924
- 主分类号： C07J31/00
- IPC分类号： C07J31/00
![Process for the manufacture of 7-alpha-[9-(4,4,5,5,5-penta fluoropentylsulphinyl) nonyl]estra-1,3,5-(10)- triene-3,17-beta-diol](/abs-image/US/2010/07/08/US20100174101A1/abs.jpg.150x150.jpg)
摘要：
The present invention provides a novel multi-step process for the manufacturing Fulvestrant, which is economical and convenient to operate at commercial scale, and requires only simple chromatographic separations after the coupling step of adding the side chain to the 7 position of the steroid.
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